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Altenuene

SKU: orb1683172

Description

Altenuene

Research Area

Infectious Disease & Virology

Images & Validation

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Altenuene

Key Properties

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CAS Number29752-43-0
MW292.28
Purity98.32% (May vary between batches)
FormulaC15H16O6
SMILESC[C@@](C[C@H]1O)(C(c2cc(OC)cc(O)c22)=C[C@H]1O)OC2=O
TargetAntifection

Bioactivity

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In Vitro
METHODS AND RESULTS:Two new polyketides, 7-hydroxy-3, 5-dimethyl-isochromen-1-one (1) and 6-hydroxy-8-methoxy-3a-methyl-3a,9b-dihydro-3H-furo[3,2-c]isochromene-2,5-dione (2), along with eleven known compounds, 5'-methoxy-6-methyl-biphenyl-3,4,3'-triol (3), 7-hydroxy-3-(2-hydroxy-propyl)-5-methyl-isochromen-1-one (4), rubralactone (5), isoAltenuene (6), Altenuene (7), dihydroAltenuenes A (8), altenusin (9), alterlactone (10), 6-O-methylnorlichexanthone (11), norlichexanthone (12), and griseoxanthone C (13) were isolated from the culture of the endolichenic fungus Ulocladium sp. Compound 2 was obtained as a racemate with an unprecedented chemical skeleton. The NMR data assignments for 3 and 4 were achieved for the first time. Compounds 1-13 were screened for their antimicrobial and radical scavenging activities. CONCLUSIONS: Compound 1 showed some antifungal activity against Candida albicans SC 5314 with IC(50) of 97.93 ± 1.12 μM. Compounds 11-13 showed strong activity against Bacillus subtilis with IC(50) in the range of 1-5 μM. Compound 12 significantly inhibited the growth of methicillin-resistant Staphylococcus aureus with IC(50) of 20.95 ± 1.56 μM. Compounds 9 and 10 showed strong radical scavenging activity in comparison with vitamin C. The plausible biosynthetic pathways for compounds 1, 2, and 4-8 were discussed.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Altenuene, Antifection

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Compound Identifiers

PubChem CID
11645000 ↗

Key Properties

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No computed properties available.

Protocol Information

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1 mg
$ 290.00
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