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AP21998

SKU: orb3175008

Description

AP21998 is a selective ligand for the Fm (mutant FKBP) domain that binds to a single FKBPv. It disrupts FKBP-mediated oligomerization, inhibits the proliferation of transformed myeloid progenitors, and promotes their terminal myeloid differentiation. AP21998 destabilizes aggregates of CAD-hM1 receptor fusion proteins, allowing receptors to exit the endoplasmic reticulum and reach the plasma membrane. AP21998 is applicable in cancer research.

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

Key Properties

CAS Number292606-90-7
MW777.96
FormulaC43H59N3O10
SMILES[C@H](C(=O)N1[C@H](C(O[C@H](CCC2=CC(OC)=C(OC)C=C2)C3=CC(OCC(NCCCN(C)C)=O)=CC=C3)=O)CCCC1)(CC)C4=CC(OC)=C(OC)C(OC)=C4
TargetFKBP

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information