Atogepant

SKU: orb1986976

Description

Atogepant is a potent and selective oral antagonist of the calcitonin gene-related peptide (CGRP) receptor. It is a valuable research tool for studying migraine pathophysiology, utilized in both in vitro binding assays and in vivo preclinical models of migraine.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1374248-81-3
MW	603.52
Purity	99.77% (May vary between batches)
Formula	C₂₉H₂₃F₆N₅O₃
SMILES	O=C1[C@@]2(C=3C(N1)=NC=CC3)CC=4C(C2)=NC=C(C(N[C@H]5C[C@H]([C@@H](C)N(CC(F)(F)F)C5=O)C6=C(F)C(F)=CC=C6F)=O)C4
Target	CGRP Receptor
Solubility	DMSO:80 mg/mL (132.56 mM)

Bioactivity

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Target IC50	CGRP receptors (rabbit):2.1 nM (Ki)\|CGRP receptors (human cloned):0.015 nM (Ki)\|CGRP receptors (rhesus macaque):0.009 nM (Ki)\|CGRP receptors (dog):1.2 nM (Ki)\|CGRP receptors (human natural):0.026 nM (Ki)\|CGRP (human cloned):0.026 nM\|CGRP receptors (mouse):0.13 nM (Ki)\|CGRP receptors (rat):0.7 nM (Ki)
In Vivo	Oral administration of Atogepant to rats (at doses of 3, 10, and 30 mg/kg, respectively) once daily for 9 days showed that Atogepant effectively attenuated the abnormal facial pain induced by nitroglycerin and ameliorated the capsaicin-induced vasodilation of primate dermis in rats.
In Vitro	Atogepant has a CGRP IC50=0.026 nM for human clones. The binding affinities of Atogepant for human and non-human CGRP receptors were: human (cloned) Ki=0.015 nM, human (natural) Ki=0.026 nM, rhesus macaque Ki=0.009 nM, rat Ki=0.7 nM, mouse Ki=0.13 nM, rabbit Ki=2.1 nM, dog Ki=1.2 nM, respectively.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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MK 8031, MK8031, MK-8031, MK8031. Atogepant, CGRP, CGRPReceptor, CGRP Receptor, Atogepant, AGN241689, AGN-241689

Quality Guarantee

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Compound Identifiers

PubChem CID

72163100 ↗

Key Properties

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No computed properties available.

Protocol Information

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MW:	603.52
Formula:	C₂₉H₂₃F₆N₅O₃

Atogepant

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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