Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

AZD-0284

SKU: orb1308615

Description

AZD-0284

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number2101291-07-8
MW524.43
Purity99.82% (May vary between batches)
FormulaC21H18F6N2O5S
SMILESCC(=O)N1Cc2cc(ccc2[C@@H]1C(=O)Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(C)(=O)=O
TargetROR
Solubility10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (1.91 mM);DMSO:99 mg/mL (188.78 mM)

Bioactivity

Target IC50
RORγ:7.4(pIC50)
In Vitro
AZD0284 (0.37 μM; 5 days) inhibits IL-17A production in human TH17 cells, reduces polarization of TH17 into pathogenic TH17/1 cells, decreases the frequency of IL-17+ cells and double positive TH17/1 cells, and reduces IL-17A secretion and RNA expression of IL-17A, IL-17F, IL-22, and IL-23R.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, Inhibitor, IL-17F, IL-17A, IL-22, L-23R, cells, AZD 0284, AZD0284, AZD-0284, RAR-related orphan receptor, tract, plaque, production, ROR, RORγ, respiratory, psoriasis, TH17, vulgaris
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 80.00
5 mg
$ 140.00
1 ml x 10 mM (in DMSO)
$ 160.00
10 mg
$ 190.00
25 mg
$ 270.00
50 mg
$ 370.00
DispatchUsually dispatched within 5-10 working days
Bulk Enquiry