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Neurological Biomarkers
CGRP: A Biomarker for Migraine
Exploring the role of Calcitonin Gene-Related Peptide in migraine pathology and advanced reagents for therapeutic research.
Migraine is a widespread and debilitating condition that impacts the lives of hundreds of millions of people globally. Since the 1990s, there has been significant progress in understanding migraines, leading to the development of novel treatments aimed at drastically reducing the personal and economic burden on patients.
These cutting-edge treatments specifically target the calcitonin gene-related peptide (CGRP) and actively include monoclonal antibodies against CGRP ligands or receptors, as well as small molecule antagonists for CGRP receptors. Despite these massive advancements, some patients do not respond to these treatments, emphasizing the profound ongoing need for accurate biomarkers in managing migraines effectively.
1. Structure & Physiological Roles
CGRP is a potent neuropeptide that plays a significant regulatory role in the nervous system and is intimately involved in various physiological processes.
CGRP Structure
- CGRP is a highly conserved 37-amino acid peptide.
- It is natively produced in both the central and peripheral nervous systems.
- CGRP exists fundamentally in two distinct forms: alpha-CGRP and beta-CGRP, which are encoded by entirely different genes but share remarkably similar physiological functions.
Physiological Roles
- Vasodilation: CGRP is an incredibly potent vasodilator, meaning it can rapidly widen blood vessels. This is critically important in naturally regulating local blood flow and systemic blood pressure.
- Pain Transmission: It is heavily involved in the active transmission of neurological pain signals, particularly in the specific context of migraine headaches.
- Neurotransmission: CGRP actively acts as both a neurotransmitter and neuromodulator, deeply influencing various downstream neuronal functions.
2. CGRP and Migraines
The Mechanism of Action
During a migraine attack, calcitonin gene-related peptide (CGRP) levels aggressively rise in both the peripheral blood and the cerebrospinal fluid. This powerful neuropeptide directly contributes to the migraine pathology by causing the massive dilation of cerebral blood vessels (vasodilation) and violently activating the trigeminal nerve, which is exclusively responsible for transmitting cranial pain signals. The combined synergistic effect of these cellular actions leads directly to the characteristic severe pain, throbbing, and other sensory symptoms associated with clinical migraines.
3. CGRP Research Reagents
To confidently aid your therapeutic research, Biorbyt offers highly validated ELISA kits, purified recombinant proteins, targeted antibodies, and highly specific small molecule products for accurately measuring and manipulating CGRP across various species. Below are some of our most trusted, best-selling CGRP reagents:
CGRP ELISA Kits
| Cat. Code | Product Name |
|---|---|
| orb438605 | Human CGRP ELISA Kit |
| orb775074 | Human CGRP1 (Calcitonin Gene Related Peptide 1) ELISA Kit |
| orb776257 | Mouse CGRP1 (Calcitonin Gene Related Peptide 1) ELISA Kit |
| orb774903 | Mouse CGRP2 (Calcitonin Gene Related Peptide 2) ELISA Kit |
| orb776256 | Rat CGRP1 (Calcitonin Gene Related Peptide 1) ELISA Kit |
| orb775295 | Rat CGRP2 (Calcitonin Gene Related Peptide 2) ELISA Kit |
| orb1146908 | Chicken CGRP1 (Calcitonin Gene Related Peptide 1) ELISA Kit |
| orb779840 | Dog CGRP1 (Calcitonin Gene Related Peptide 1) ELISA Kit |
| orb1291353 | Pig CGRP2 (Calcitonin Gene Related Peptide 2) ELISA Kit |
CGRP Recombinant Proteins
| Cat. Code | Product Name |
|---|---|
| orb54331 | Recombinant Human Calcitonin gene-related peptide 2 (CALCB) |
| orb358731 | Recombinant Dog Calcitonin (CALCA) |
CGRP Antibodies
| Cat. Code | Product Name |
|---|---|
| orb10379 | CALCA (Calcitonin gene-related peptide 1/Alpha-type CGRP) antibody |
| orb182870 | CGRP (Calcitonin gene-related peptide 1/Alpha-type CGRP) antibody |
| orb357919 | CGRP (Calcitonin gene-related peptide 2/Beta-CGRP) antibody |
| orb647197 | CGRP (Calcitonin gene-related peptide 2/Beta-CGRP) antibody |
CGRP Small Molecules
| Cat. Code | Product Name |
|---|---|
| orb1708126 | CGRP antagonist 1 |
| orb321008 | Human CGRP |
| orb1296388 | α-CGRP (human) acetate |
Need Assistance with Your Assay Design?
If you have any questions or wish to discuss any of these specialized products further, please feel free to reach out to our Technical Support team at [email protected]. We are here to assist you and look forward to helping you with your diagnostic inquiries.