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Desfluoro-BMS-694153

SKU: orb3174814

Description

Desfluoro-BMS-694153 (Compound 3) is an antagonist of the calcitonin gene-related peptide receptor (CGRP receptor) with a Ki of 0.01 nM. It exhibits a significantly reduced risk of CYP3A4 inhibition, with IC50 values of 36 μM for CYP3A4-BFC and 6 μM for CYP3A4-BZR. Desfluoro-BMS-694153 is useful for migraine research.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number773886-89-8
MW626.81
FormulaC35H46N8O3
SMILESO=C1N(CC=2C(N1)=CC=CC2)C3CCN(C(N[C@H](CC=4C=C5C(=C(C)C4)NN=C5)C(=O)N6CCC(CC6)N7CCCCC7)=O)CC3
TargetCytochromes P450,CGRP Receptor

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information