Deucravacitinib

SKU: orb1308545

Description

Deucravacitinib (BMS-986165) is an oral, allosteric inhibitor that selectively targets the TYK2 pseudokinase (JH2) domain with high potency (IC50 = 1.0 nM). It functions by stabilizing this regulatory domain, thereby blocking IL-12, IL-23, and type I interferon signaling pathways. This mechanism supports its research application in studying autoimmune disease models, both in vitro and in vivo.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	1609392-27-9
MW	425.46
Purity	99.43% (May vary between batches)
Formula	C₂₀H₁₉D₃N₈O₃
SMILES	[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC
Target	Tyrosine Kinases\|\|\|JAK\|\|\|Interleukin\|\|\|IFNAR
Solubility	10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (7.76 mM);DMSO:84.2 mg/mL (197.9 mM)

Bioactivity

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Target IC50	IL-12:2–19 nM\|Tyk2 JH2:0.2 nM\|IFN-α:2–19 nM\|IL-23:2–19 nM\|JAK1 JH2:1 nM
In Vivo	METHODS: When mirdametinib was used in combination with Deucravacitinib (BMS-986165) (40 μM) in JW23.3 cells, cell growth was observed. RESULTS Both drugs synergistically inhibited cell proliferation and increased cell apoptosis compared to either drug alone.
In Vitro	METHODS: The mean daily percent inhibition of TYK2 was simulated by Deucravacitinib (BMS-986165) (6 mg/12 mg once daily) at clinically relevant concentrations. RESULTS Deucravacitinib (BMS-986165) had minimal effects on IL-2-induced STAT5 phosphorylation (JAK 1/3) and TPO-induced STAT3 phosphorylation (JAK 2/2).

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Deucravacitinib, BMS 986165, BMS986165, BMS-986165, IFNAR, Inhibitor, Interleukin Related, Interleukin, Interferon-α/β receptor, Interferon-alpha/beta receptor, Janus kinase, JAK1-JH2, JAK1 JH2, JAK, inhibit, Tyk2 JH2, TyrosineKinases, Tyrosine Kinases

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Compound Identifiers

PubChem CID

134821691 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

CAS Number:	1609529-70-5
MW:	515.54
Formula:	C₂₇H₂₆FN₇O₃

Deucravacitinib

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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