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DM245

SKU: orb3211013

Description

DM245 serves as an EPAC1 activator and a STAT3 phosphorylation inhibitor, with a target pIC50 of 4.801. It enhances Rap1-GTP levels by activating EPAC1 without affecting EPAC2 or PKA. Additionally, DM245 reduces IL-6/IL-6Rα-induced STAT3 phosphorylation in endothelial cells and inhibits TGF-β1-induced fibroblast-to-myofibroblast transformation, decreasing αSMA and type I collagen levels.

Images & Validation

Key Properties

CAS Number3106606-60-1
MW415.44
FormulaC25H21NO5
SMILESO=C(O)C(=O)NCC=1C=CC=2OC(C(=O)C=3C=CC=4C=CC=CC4C3)=C(C2C1)C(C)C
TargetSTAT,Acyltransferase

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information