DPP-1-IN-2

DPP-1-IN-2 is a potent DPP-I inhibitor with a human IC50 of 36.8 nM and demonstrates oral efficacy. It binds to DPP-I within cells, enhancing its thermal stability and inhibiting its enzymatic activity, thereby reducing the activity and expression levels of downstream neutrophil serine proteases. Additionally, DPP-1-IN-2 modulates the secretion of inflammatory cytokines and chemokines, exerting anti-inflammatory effects. It can reverse joint inflammation and tissue damage in an adjuvant-induced arthritis rat model and is applicable for research related to arthritis.