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Description

ED11 is a potent, selective, and brain-penetrant caspase-6 inhibitor (IC50 = 12.12 nM) that reduces mutant huntingtin cleavage by competing for the enzyme's active site. It is a valuable research tool for investigating Huntington's disease mechanisms in both cellular and animal models.

Research Area

Cell Biology, Protein Biochemistry

Images & Validation

Key Properties

TargetCaspase
CAS Number1593480-56-8
MW2850.16
FormulaC116H205N47O37
SMILESC(=O)([C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)NC(CN)=O)=O)CCCCN)=O)CCCCN)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC1)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(O)=O)=O)CC(O)=O)=O)[C@@H](C)O)=O)=O)CC(O)=O)=O)CC(C)C)=O)C(C)C)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CO)=O)CO)=O)CCC(N)=O)=O)CCC2

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Protein Handling and Storage Guide
Protein Handling Guide
View Guide