Fibrinogen

SKU: orb2278668

Description

Fibrinogen, a thrombin-cleavable heterodimeric protein, serves as a key biomarker in cardiovascular disease research and metabolic studies. Its deficiency leads to fibrinogenemia. This protein is widely utilized in vitro for coagulation assays and in vivo for modeling hemostasis and thrombosis.

Research Area

Cardiovascular Research, Immunology & Inflammation, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	9001-32-5
Target	NF-κB,Interleukin

Bioactivity

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In Vitro

Confluent MVECs were serum starved for 16 h and incubated with one of the following: Fibrinogen (2 or 4 mg/ml), Fibrinogen (4 mg/ml) with antibody against ICAM-1 (50 μM), Fibrinogen (4 mg/ml) with antibodies against α5 and β1, or β3 integrins (50 μM each), or Fibrinogen (4 mg/ml) with MEK inhibitors PD98059 or U0126 (50 μM each) at 37°C for 30 min. Fibrinogen induced a distinct dose-dependent increase of ERK phosphorylation that was significantly decreased by the presence of MEK inhibitors, PD98059 or U0126. Treatment of ECs with PD98059 (0.44 ± 0.03 FIU/cell, n = 4) or U0126 (0.40 ± 0.02 FIU/cell, n = 4), did not alter ERK phosphorylation in ECs compared to that in the control group (0.50 ± 0.05 FIU/cell, n = 4).

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Interleukin Related, NFkB, NF-kB, NF-κB, NFκB

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Quick Database Links

Gene Symbol

NF-κB,Interleukin

Protocol Information

Find More Protocols

Applications:	ICC, IF, IHC-P, WB
Reactivity:	Mouse, Porcine, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, ICC, IHC, WB
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, ICC, IF, IHC, WB
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	IF, IHC-Fr, IHC-P, WB
Predicted Reactivity:	Bovine, Canine, Porcine, Rabbit, Sheep
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Fibrinogen

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

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FGA Antibody [orb3160564]

FGG Antibody [orb3160781]

GSK3 beta/GSK3B Rabbit Polyclonal Antibody [orb1290012]

Angiopoietin-like 4 Rabbit Polyclonal Antibody [orb101848]

Quality Guarantee

Quick Database Links

Protocol Information

Available Sizes

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