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GLPG4471

SKU: orb3173840

Description

GLPG4471 is a selective and orally active IRAK4 inhibitor with an IC50 of 1.7 nM. It demonstrates potent inhibitory effects on cytokine secretion (TNFα and IFNα) in both cellular and whole blood phenotypic assays. Additionally, GLPG4471 shows significant activity in a collagen-induced arthritis mouse model and can be utilized for arthritis research.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number2499855-36-4
MW410.47
FormulaC22H26N4O4
SMILESO=C(NC1=CC2=CC(=NN2C=C1OC)CCC(O)(C)C)C3=CC=CN(C3=O)C4CC4
TargetTNF,IRAK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

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Protocol Information