Glucosamine

SKU: orb1310625

Description

Glucosamine is a naturally occurring amino sugar used as a dietary supplement and research compound. It is studied for its effects on cartilage metabolism in osteoarthritis models and its role in modulating glucose regulation, as evidenced by its impact on glucokinase activity in pancreatic islet homogenates.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	3416-24-8
MW	179.17
Purity	99.80% (May vary between batches)
Formula	C₆H₁₃NO₅
SMILES	N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO
Target	Autophagy,MMP,Reactive Oxygen Species,CFTR,TNF,ROS,HIF/HIF Prolyl-Hydroxylase,NF-κB,Endogenous Metabolite
Solubility	H2O:200.9 mM;DMSO:58 mg/mL (323.71 mM)

Bioactivity

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Target IC50	superoxide:47.67 mM (IC20)\|DPPH:21.32 mM\|hydroxyl:14.04 mM
In Vivo	METHODS: To study the effect of Glucosamine on bone injury, Glucosamine (20 mg/kg/day) was orally administered to mice for 30 consecutive days. RESULTS: Glucosamine significantly reduces cartilage damage and osteophyte formation.
In Vitro	METHODS: YD-8 human tongue cancer cells were treated with Glucosamine (10 mM) for 4 hours, and the phosphorylation levels of related proteins were detected by western blot. RESULTS: Glucosamine inhibits HIF-1α and reduces the phosphorylation of p70S6K and S6 translation-related proteins. METHODS: Renal cells were treated with Glucosamine (5 mM) for 12, 24 and 36 hours, and the expression level of target proteins was detected by western blot. RESULTS: Glucosamine significantly reduced the renal expressions of α -smooth muscle actin, collagen I and fibronectin in obstructive kidneys and renal cells treated with TGF-β1.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Glucosamine, EndogenousMetabolite, Endogenous Metabolite, HIF-PH, HIFs, HIFProlylHydroxylase, Inhibitor, Hypoxia-inducible factors, IFγ, HIF ProlylHydroxylase, HIF, HIF/HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF/HIFProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, inhibit, NF-kB, NF-κB, NFκB, NFkB, MMP-9, Chitosanase, Chitosamine, D-Glucosamine, Autophagy, ReactiveOxygenSpecies, TNF-α, Reactive Oxygen Species

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Compound Identifiers

PubChem CID

3034366 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

Applications:	ELISA, ICC, IHC, WB
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, ICC, IHC, WB
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Reactivity:	Rat
Dynamic Range:	0.63-40 ng/mL
Sensitivity:	0.255 ng/mL

Applications:	FC, IHC-P, WB
Predicted Reactivity:	Mouse, Rat
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	FC, IHC-P, WB
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Glucosamine

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Key Properties

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