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GSK1370319A

SKU: orb1737810

Description

GSK1370319A is a potent and selective P2X7 receptor antagonist (IC50 = 3.2 nM) that blocks NLRP3 inflammasome assembly and IL-1β release in glial cells. It is a valuable research tool for studying neuroinflammation, demonstrating protective effects against neuronal loss in vitro and age-related synaptic deficits ex vivo.

Images & Validation

Key Properties

CAS Number1001389-31-6
MW301.17
FormulaC13H14Cl2N2O2
SMILESC(NCC1=C(Cl)C=C(Cl)C=C1)(=O)[C@H]2N(C)C(=O)CC2
TargetOthers

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

Protocol Information