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Human IL-18 Protein, Research Grade

SKU: orb3158165

Description

Interleukin-18 (IL-18) is a potent proinflammatory cytokine that induces interferon-gamma (IFN-gamma) production from Th1 cells, NK cells and activated macrophages, particularly in the presence of IL-12. IL-18 also functions in developmental regulation of T-lymphocyte helper type I cells and in Fas-mediated cytotoxicity. Suppression of IL-18 activity is being investigated for treatment of chronic inflammatory diseases such as Crohn's disease and rheumatoid arthritis. It acts by inducing heterodimerization of the two subunits of its receptor, IL-18RAlpha and IL-18RBeta shows structural similarity to IL-1.

Research Area

Immunology & Inflammation

Images & Validation

Application Notes
This protein carries no "tag". The protein has a calculated MW of 18.2 kDa. The protein migrates as 17 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

Key Properties

Expression SystemE. coli
TargetIL-18
ReactivityHuman
TagNative
Expression RegionTyr 37 - Asp 193
Endotoxins0.01 EU per μg
ConjugationUnconjugated
MW18.2 kDa
Purity95%

Storage & Handling

Storage-20°C
Form/AppearancePowder
Buffer/PreservativesPBS, pH 7.4
Expiration Date6 months from date of receipt.
DisclaimerFor research use only

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NCBI Reference Sequences

Associated Accession Numbers
Curated reference sequences for the gene transcript and protein product
RefSeqQ14116

Protocol Information

Protein Handling and Storage Guide
Protein Handling Guide
View Guide