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Indobufen

SKU: orb1940718

Description

Indobufen is an inhibitor of platelet aggregation and is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes.(In Vitro):Indobufen suppresses TxA2 but not PGE2 synthesis in LPS-stimulated monocytes. Indobufen causes the extent of ERK1/2 phosphorylation, whereas the levels of phosphorylated p38 are unaltered. Indobufen does not affect both Cox-1 and Cox-2 protein, whereas Indobufen reduces TxB2 levels.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Indobufen

Key Properties

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CAS Number63610-08-2
MW295.338
Purity>98% (HPLC)
FormulaC18H17NO3
SMILESCCC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O
TargetCOX
SolubilityIn Vitro: DMSO : 250 mg/mL (846.51 mM)

Bioactivity

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In Vitro
Indobufen does not affect both Cox-1 and Cox-2 protein, whereas Indobufen reduces TxB2 levels. Indobufen inhibits TxA2 but not PGE2 synthesis in LPS-stimulated monocytes. Indobufen reduces the extent of ERK1/2 phosphorylation, whereas the levels of phosphorylated p38 are unaltered.

Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Ibustrin

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Quick Database Links

Gene Symbol
COX

Protocol Information

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1 g
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