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JC124

SKU: orb1702158

Description

JC124 is a selective small molecule inhibitor of the NLRP3 inflammasome. It demonstrates neuroprotective and anti-inflammatory effects, making it a valuable research tool for studying NLRP3-driven pathologies in models of neurodegenerative and inflammatory diseases both in vitro and in vivo.

Research Area

Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number1638611-48-9
MW382.86
Purity99.64% (May vary between batches)
FormulaC17H19ClN2O4S
SMILESCNS(=O)(=O)c1ccc(CCNC(=O)c2cc(Cl)ccc2OC)cc1
TargetNOD,NOD-like Receptor (NLR)
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (13.06 mM);DMSO:225 mg/mL (587.68 mM)

Bioactivity

In Vivo
In adult male Sprague-Dawley rats bearing traumatic brain injury, intraperitoneal administration of JC124 (100 mg/kg) reduces the number of injury-induced degenerating neurons, inflammatory cell response, and cortical lesion volume. JC124 decreases the expression of NLRP3, IL-1 beta, TNFα, ASC, iNOS, and caspase-1.
In Vitro
JC124 selectively inhibits NLRP3 inflammasome formation and activates caspase-1, and reduces IL-1β.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

JC124, JC-124, JC 124, NLRP3
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 100.00
5 mg
$ 190.00
1 ml x 10 mM (in DMSO)
$ 210.00
10 mg
$ 280.00
25 mg
$ 440.00
50 mg
$ 610.00
100 mg
$ 810.00
200 mg
$ 1,030.00
DispatchUsually dispatched within 5-10 working days
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