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JC2-11

SKU: orb1819061

Description

JC2-11 is a small molecule inhibitor that suppresses inflammasome activation by targeting NLRC4 and AIM2 pathways. It disrupts ROS production and caspase-1 activity, thereby reducing GSDMD cleavage, IL-1β maturation, and LDH release. This compound is a valuable research tool for studying pyroptosis and inflammation in both cellular and animal models of inflammatory diseases.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Protein Biochemistry

Images & Validation

Key Properties

CAS Number937820-89-8
MW302.3
Purity99.88% (May vary between batches)
FormulaC17H15FO4
SMILESC(/C=C/C1=CC(OC)=C(O)C=C1)(=O)C2=CC(F)=C(OC)C=C2
TargetROS,IL Receptor,AIM2,NOD-like Receptor (NLR),Caspase,Dehydrogenase
SolubilityDMSO:127.5 mg/mL (421.77 mM)

Bioactivity

In Vivo
JC2-11 (250 μg/mouse; i.p.; single dose) significantly inhibited the release of caspase-1 (p20) and IL-1β from the non-canonical (NC) inflammasome in the C57BL/6 mouse model, attenuated NC inflammasome activation.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

LDH, NODlikeReceptor(NLR), NODlikeReceptor, NOD-like Receptor (NLR), NOD-like Receptor, NODlike Receptor (NLR), NLR, JC211, JC2-11, IL Receptor, IL-1β, ILReceptor, Caspase-1, AIM2, ROS
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 80.00
5 mg
$ 130.00
1 ml x 10 mM (in DMSO)
$ 140.00
10 mg
$ 190.00
25 mg
$ 340.00
50 mg
$ 530.00
100 mg
$ 760.00
500 mg
$ 1,520.00
DispatchUsually dispatched within 5-10 working days
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