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Lasofoxifene

SKU: orb1687919

Description

Lasofoxifene (CP-336156) is a selective estrogen receptor modulator (SERM) with antagonist properties. It is utilized in breast cancer research for its ability to inhibit primary tumor growth and metastasis, supported by studies showing it reduces IL-6 and inflammation in models of arthritis and osteoporosis.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number180916-16-9
MW413.55
Purity99.60% (May vary between batches)
FormulaC28H31NO2
SMILESOC=1C=C2C([C@H]([C@H](CC2)C3=CC=CC=C3)C4=CC=C(OCCN5CCCC5)C=C4)=CC1
TargetEstrogen Receptor/ERR
SolubilityDMSO:6.5 mg/mL (15.72 mM)

Bioactivity

In Vivo
Methods: Lasofoxifene (1, 5, and 10 mg/kg, 5 times per week) was administered subcutaneously to NSG mice with established human-derived xenograft models (MIND models) to assess the antitumor activity of lasofoxifene in endocrine therapy-resistant ER+ breast cancer mouse models. Results: Lasofoxifene demonstrated superior efficacy in inhibiting tumor growth and metastasis compared to fulvestrant, especially in Y537S and D538G mutant tumors, where lasofoxifene showed stronger inhibitory effects.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CW008, CW-008

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Key Properties

No computed properties available.

Protocol Information

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2 mg
$ 80.00
5 mg
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