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Necrostatin-34

SKU: orb1298374

Description

Necrostatin-34 is a potent and selective RIPK1 kinase inhibitor that stabilizes the kinase in an inactive state. It is widely used in research to investigate necroptosis in both cellular and animal models of inflammatory and degenerative diseases.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number375835-43-1
MW384.5
Purity>98%
FormulaC18H16N4O2S2
SMILESCc1ccc(cc1)C1CC(=O)NC(SCC(=O)Nc2nccs2)=C1C#N
TargetKinase
SolubilitySoluble in DMSO (up to at least 25 mg/ml)

Bioactivity

In Vitro
Necrostatin-34 (10 μM) inhibits the dimerization-induced RIPK1 activation as examined by phosphorylation of Ser166 (p-S166) of RIPK1, a biomarker for RIPK1 activation. Necrostatin-34 may block TNFα-induced complex II formation by inhibiting the activation of RIPK1 kinase. Necrostatin-34 shows IC50 values of 667 nM and 134 nM for TNFα in FADD def-Jurkat cells and L939 cells, respectively.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Nec-34; 2-((3-Cyano-6-oxo-4-(p-tolyl)-1,4,5,6-tetrahydropyridin-2-yl)thio)-N-(thiazol-2-yl)acetamide

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  • Necrostatin-34 [orb1218091]

    >98% (HPLC)

    375835-43-1

    384.48

    C18H16N4O2S2

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 g, 500 mg
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Key Properties

No computed properties available.

Protocol Information

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5 mg
$ 230.00
25 mg
$ 460.00
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