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NEK7 degrader-2

SKU: orb3181400

Description

NEK7degrader-2 (Compound 25) serves as a NEK7 degrader. It demonstrates a dose-dependent ability to degrade NEK7 in macrophages derived from human peripheral blood mononuclear cells, and reduces the release of the pro-inflammatory cytokine IL-1β, induced by NLRP3 inflammasome activation. NEK7degrader-2 is applicable for research into inflammatory diseases.

Research Area

Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number3037413-54-7
MW341.41
FormulaC19H23N3O3
SMILESO=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2C)C4NCCCC4)CC1
TargetNOD-like Receptor (NLR),Interleukin,MAPK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information