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NLRP3-IN-45

SKU: orb2665407

Description

NLRP3-IN-45 (D6) is a potent and selective NLRP3 inflammasome inhibitor, with an IC50 of 41.79 nM against IL-1β. It blocks inflammasome assembly without affecting priming and has demonstrated efficacy in an LPS-induced acute lung injury (ALI) mouse model, supporting its use in researching NLRP3-driven inflammatory diseases.

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

Key Properties

MW483.53
FormulaC27H30FNO6
TargetNOD-like Receptor (NLR)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information