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NLRP3-IN-69

SKU: orb2944574

Description

NLRP3-IN-69 (Compound 23) is a small molecule inhibitor that blocks NLRP3 inflammasome assembly and NF-κBp65 activation. It reduces LPS-induced expression of IL-1β, iNOS, and COX-2, and inhibits nitric oxide production with an IC50 of 5.66 µM, demonstrating utility for in vitro anti-inflammatory research.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Signal Transduction

Images & Validation

Key Properties

CAS Number3027608-60-9
MW436.454
FormulaC25H24O7
SMILESO(C(/C=C/C1=CC(OC)=C(OC)C(OC)=C1)=O)C2=CC3=C(C=C([C@@H](C(O)=O)C)C=C3)C=C2
TargetInterleukin,COX,NO Synthase,NOD-like Receptor (NLR),NF-κB

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

Protocol Information