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P2X4 antagonist-4

SKU: orb2945647

Description

P2X4 antagonist-4 (compound 64) is a selective P2X4 receptor blocker (IC50 = 8 µM) that suppresses ATP-mediated NLRP3 inflammasome activation and IL-1β release. This tool compound is useful for studying neuropathic pain and neuroinflammation in both cellular and animal models of disease.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number3108486-39-8
MW503.545
FormulaC27H22FN3O4S
SMILESCC1=C(C=CC(=C1)F)CS(=O)(=O)NC2=CC=C(C=C2)N3C(=O)CC(=O)NC4=C3C=CC5=CC=CC=C54
TargetP2X Receptor

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

Protocol Information