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Peptide E5

SKU: orb3212303

Description

Peptide E5 acts as an antagonist targeting the CXCR4/CXCL12 axis. It effectively blocks this axis, reduces CXCR4 expression, and inhibits the phosphorylation of downstream proteins Akt and Erk. Peptide E5 can induce apoptosis in breast cancer cells, while also inhibiting their migration and adhesion. Furthermore, it suppresses the recruitment of endothelial progenitor cells mediated by CXCL12, thereby inhibiting tumor angiogenesis. Peptide E5 is useful for research related to breast cancer.

Images & Validation

Key Properties

TargetCaspase,Akt,CXCR,ERK,Apoptosis
CAS Number1643580-44-2
MW2613.95
FormulaC113H181N39O31S
SMILES[C@@H](CC1=CC=CC=C1)(NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](NC(CNC(CN)=O)=O)CCCNC(=N)N)=O)CO)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)CC(O)=O)=O)C(C)C)=O)[C@@H](C)O)=O)CC(N)=O)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N)=O)CS)=O)=O)CCC(N)=O)=O)[C@H](CC)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CC(C)C)=O)CC(C)C)=O

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

Protein Handling and Storage Guide
Protein Handling Guide
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