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Procyanidin B2

SKU: orb1300222

Description

Procyanidin B2

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number29106-49-8
MW578.52
Purity99.64% (May vary between batches)
FormulaC30H26O12
SMILESO[C@@H]1Cc2c(O)cc(O)c([C@@H]3[C@@H](O)[C@H](Oc4cc(O)cc(O)c34)c3ccc(O)c(O)c3)c2O[C@@H]1c1ccc(O)c(O)c1
TargetReactive Oxygen Species,ROS,NOD
SolubilityDMSO:83.33 mg/mL (144.04 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.46 mM)

Bioactivity

In Vivo
Procyanidin B2 from cinnamon inhibited AGE accumulation in diabetic rat kidney and ameliorated AGE mediated pathogenesis of DN.
In Vitro
Procyanidin B2 exerts both antioxidant and pro-oxidant properties by interacting with H2O2 and metal ions.
Animal Research
Streptozotocin-induced diabetic rats were fed with either 3% cinnamon or 0.002% Procyanidin B2(PCB2)-fraction in diet for 12weeks. Biochemical analysis of blood and urine was performed at the end of experiment. Evaluation of glomerular markers that serve as indicators of renal function was done by immunohistochemistry, immunoblotting and qRT-PCR. Supplementation of diabetic rats with cinnamon and PCB2-fraction prevented glycation mediated RBC-IgG cross-links and HbA1c accumulation in diabetes rats. Cinnamon and PCB2-fraction also inhibited the accumulation of N-carboxy methyl lysine (CML), a prominent AGE in diabetic kidney.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, inhibit, NLRP3, Reactive Oxygen Species, ReactiveOxygenSpecies, Proanthocyanidin B 2, Proanthocyanidin B2, Proanthocyanidin B-2, Procyanidin B 2, Procyanidin B2, Procyanidin B-2

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 90.00
5 mg
$ 140.00
1 ml x 10 mM (in DMSO)
$ 140.00
10 mg
$ 210.00
25 mg
$ 420.00
50 mg
$ 600.00
100 mg
$ 860.00
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