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Cholesteryl Hemisuccinate

SKU: orb1745228

Description

Cholesteryl Hemisuccinate is a water-soluble cholesterol derivative with hepatoprotective and anticancer properties. It is used in research to study mechanisms against drug-induced liver injury (e.g., acetaminophen) and to investigate inhibition of DNA polymerases and topoisomerases in vitro, impacting cell replication and repair pathways.

Research Area

Cell Biology, Molecular Biology

Images & Validation

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Key Properties

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CAS Number1510-21-0
MW486.73
Purity99.98% (May vary between batches)
FormulaC31H50O4
SMILES[H][C@@]12CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@H](CC[C@]12C)OC(=O)CCC(O)=O
TargetDNA/RNA Synthesis,Necroptosis,Topoisomerase,Apoptosis
Solubility10% EtOH+90% Corn Oil:2 mg/mL (4.11 mM);Ethanol:22.5 mg/mL (46.23 mM);DMSO:10 mg/mL (20.55 mM)

Bioactivity

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In Vivo
Cholesteryl Hemisuccinate (100 mg/kg ; ip ; single administration before AAP) eliminated AAP-induced apoptosis and necrosis in ICR mice (CD-1) for histological and biochemical diagnosis.
In Vitro
Cholesteryl Hemisuccinate (0-1000 μM) inhibited the growth of MCF-7 and MCF-10A cells.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Cholesterol hydrogen succinate, Cholesterol hydrogen Succinate, Cholesteryl, Cholesteryl Hemisuccinate, DNA polymerase, DNA Synthesis, DNASynthesis, Apoptosis, Topo, RNA Synthesis, RNASynthesis

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

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No computed properties available.

Protocol Information

Available Sizes

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500 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 80.00
1 g
$ 90.00
5 g
$ 190.00
DispatchUsually dispatched within 5-10 working days
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