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Glutathione oxidized

SKU: orb1309819

Description

Glutathione oxidized is the disulfide form of the essential cellular antioxidant glutathione. It serves as a critical research tool for investigating oxidative stress, particularly in studies of red blood cell physiology and pathologies such as sickle cell disease, in both in vitro and in vivo models.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number27025-41-8
MW612.63
Purity99.96% (May vary between batches)
FormulaC20H32N6O12S2
SMILES[C@@H](NC(CC[C@@H](C(O)=O)N)=O)(C(NCC(O)=O)=O)CSSC[C@H](NC(CC[C@@H](C(O)=O)N)=O)C(NCC(O)=O)=O
TargetEndogenous Metabolite,Glutathione reductase,ROS,Reactive Oxygen Species
SolubilityDMSO:1.39 mg/mL (2.27 mM);H2O:165 mg/mL (269.33 mM)

Bioactivity

Target IC50
[3H]-AMPA:0.8-15.9 μM
In Vivo
METHODS: To study the effect of Glutathione oxidized on brain injury, Glutathione oxidized (100 mM) was injected into wild type mice. RESULTS: Glutathione oxidized causes significant brain damage in wild type mice.
In Vitro
METHODS: Sickle erythrocytes were treated with Glutathione oxidized (10 μmol/L) for 0, 90, 150, and 210 minutes to detect the difference in GSH concentration between intracellular and extracellular. RESULTS: Increased efflux of Glutathione oxidized causes glutathione depletion and may impair the antioxidant defense of sickle erythrocytes.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Bi(glutathion-S-yl), inhibit, L(-)-Glutathione, Inhibitor, LGlutathione, L-Glutathione oxidized, Endogenous Metabolite, EndogenousMetabolite, Glutathione disulfide, Glutathione Disulfide, Glutathione oxidized, Glutathione, Glutathione reductase, Glutathionereductase, GSSG, Reactive Oxygen Species, ReactiveOxygenSpecies, Oxidized glutathione, Oxiglutatione

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 80.00
500 mg
$ 80.00
1 g
$ 90.00
DispatchUsually dispatched within 5-10 working days
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