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L1BC8

SKU: orb3028216

Description

L1BC8 (compound 13a) is a BRD4 PROTAC degrader with anticancer properties. It also serves as a drug-linker conjugate for ADC, suitable for ADC synthesis. The resulting BRD4 degrader antibody conjugates demonstrate potent antigen-dependent BRD4 degradation and antiproliferative activity in cellular assays.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number2417370-68-2
MW1745.92
FormulaC86H98F2N16O18S2
SMILESC(S(C)(=O)=O)C=1C=C2C=3C=4C(CN(C2=CC1C(NCCOC5=CC(NC(OCC6=CC=C(NC([C@@H](NC(=O)C7(C(NCCCCCN8C(=O)C=CC8=O)=O)CCC7)CCCNC(N)=O)=O)C=C6)=O)=CC(CCOCC(N[C@H](C(=O)N9[C@H](C(NCC%10=CC=C(C=C%10)C%11=C(C)N=CS%11)=O)C[C@@H](O)C9)C(C)(C)C)=O)=C5)=O)C%12=C(F)C=C(F)C=N%12)=CNC4C(=O)N(C)C3
TargetDrug-Linker Conjugates for ADC,Epigenetic Reader Domain,PROTACs

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information