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YF135

SKU: orb1983026

Description

YF135 is a reversible-covalent KRAS G12C PROTAC that degrades the oncogenic protein via VHL E3 ligase recruitment and proteasomal destruction, leading to reduced phospho-ERK signaling. This bifunctional molecule, derived from MRTX849 and a VHL ligand, is a valuable chemical tool for investigating KRAS-driven cancers in both cellular and animal models.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Key Properties

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CAS Number2913177-53-2
MW1179.86
FormulaC63H75ClN12O7S
SMILESCc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCCN2CCC[C@H]2COc2nc3CN(CCc3c(n2)N2CCN([C@@H](CC#N)C2)C(=O)C(=C\C2CC2)\C#N)c2cccc3cccc(Cl)c23)C(C)(C)C)cc1
TargetPROTACs,Ras,Kras,ERK

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

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No computed properties available.

Protocol Information