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PROTAC IRAK4 degrader-13

SKU: orb3136269

Description

PROTACIRAK4 degrader-13 (Degrader 1) is a selective IRAK4 PROTAC degrader, demonstrating DC50 values of 0.86 nM and 1.1 nM in monocytes and lymphocytes within PBMCs, respectively. It significantly induces TIR signaling activation and inhibits the expression of circulating pro-inflammatory cytokines in a psoriasis mouse model induced by Imiquimod. PROTACIRAK4 degrader-13 is applicable in the study of neutrophilic inflammatory diseases driven by TLR and IL-1R, such as hidradenitis suppurativa (HS) and atopic dermatitis (AD).

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number2432992-21-5
MW843.94
FormulaC44H52F3N9O5
SMILESC(C1=C2C(N(C(=O)N2C)C3C(=O)NC(=O)CC3)=CC=C1)N4CCC(N(C[C@@H]5CC[C@H](CC5)N6C=C7C(=N6)C=C(C(C)(C)O)C(NC(=O)C=8N=C(C(F)(F)F)C=CC8)=C7)C)CC4
TargetInterleukin,IRAK,PROTACs,TLR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information