Rapamycin

SKU: orb1224781

Description

A macrolide compound that has potent immunosuppressive and antiproliferative properties by inhibiting mTOR (IC50=0.1 nM).Other Indication Approved(In Vitro):Rapamycin (GMP) (1 nM; 2-3 weeks) induces in vitro differentiation of human embryonic stem cell (hESCs) into mineralized osteoblasts.Rapamycin (GMP) (1 nM; 2-3 weeks) enhances the osteoblastic differentiation of human embryoid bodies (hEBs).Rapamycin (GMP) (20 nM; 4 h) serum-dependently promotes vascular smooth muscle cells (VSMCs) differentiation.Rapamycin (GMP) induces osteoblastic differentiation in rat osteoblast-like osteosarcoma cells.

Images & Validation

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Key Properties

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CAS Number	53123-88-9
MW	914.1719
Purity	>98% (HPLC)
Formula	C₅₁H₇₉NO₁₃
SMILES	C[C@@H](C([C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(C[C@@H]([C@H](C)C[C@@H]1CC[C@@H](O)C(OC)C1)OC2=O)=O)=O)C[C@H](C)/C=C/C=C/C=C(C)/[C@@H](OC)C[C@H]3O[C@](C(C(N4[C@H]2CCCC4)=O)=O)(O)[C@H](C)CC3
Target	mTOR
Solubility	DMSO: ≥ 28 mg/mL

Bioactivity

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In Vitro

Rapamycin (GMP) (1 nM; 2-3 weeks) induces in vitro differentiation of human embryonic stem cell (hESCs) into mineralized osteoblasts. Rapamycin (GMP) (1 nM; 2-3 weeks) enhances the osteoblastic differentiation of human embryoid bodies (hEBs). Rapamycin (GMP) (20 nM; 4 h) serum-dependently promotes vascular smooth muscle cells (VSMCs) differentiation. Rapamycin (GMP) induces osteoblastic differentiation in rat osteoblast-like osteosarcoma cells.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Sirolimus

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Applications:	FC, ICC, IF, IHC-Fr, IHC-P, WB
Predicted Reactivity:	Bovine, Canine, Equine, Gallus, Goat, Rabbit, Sheep
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Sizes Available: 50 μl, 100 μl, 200 μl

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Phospho-mTOR (Ser2481) Rabbit Polyclonal Antibody [orb6453]

Applications:	FC, ICC, IF, IHC-Fr, IHC-P, WB
Predicted Reactivity:	Canine, Equine, Porcine, Rabbit, Sheep
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
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Applications:
ELISA, ICC, IF, IHC
Reactivity:
Human, Mouse, Rat
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Unconjugated
Sizes Available: 50 μl, 100 μl
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MLST8 Rabbit Polyclonal Antibody [orb1786046]
Applications:
ELISA, FC, ICC, IF, IHC, WB
Reactivity:
Human, Mouse, Rat
Species/Host:
Rabbit
Clonality:
Polyclonal
Conjugation:
Unconjugated
Sizes Available: 100 μg

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Gene Symbol

mTOR

Protocol Information

Find More Protocols

Applications:	ELISA, ICC, IHC, WB
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, ICC, IF, IHC
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, FC, ICC, IF, IHC, WB
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Rapamycin

Description

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

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Quality Guarantee

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