S- (+)-Rolipram

S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.(In Vitro):(+)-Rolipram (0.015-1000 μM; 20 h) dose-dependently suppress LPS-induced TNF production of human mononuclear cells (MNC), with an IC50 of 550 nM.(In Vivo):(+)-Rolipram (0.025-6.25 mg/kg; a single i.p.) dose-dependently inhibits locomotor activity and induces head twitches in rats.(+)-Rolipram (0.06-25 mg/kg; a single i.p.) causes a dose-related fall in rectal temperature of rats.