Serotonin

SKU: orb1297148

Description

Serotonin (5-HT) is an endogenous monoamine neurotransmitter and 5-HT receptor agonist that modulates central nervous, digestive, and cardiovascular functions. It is widely used in neuroscience, pharmacology, and physiology research for in vitro receptor studies and in vivo investigations of mood, cognition, and gut-brain axis signaling.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	50-67-9
MW	176.22
Purity	99.98% (May vary between batches)
Formula	C₁₀H₁₂N₂O
SMILES	NCCc1c[nH]c2ccc(O)cc12
Target	Endogenous Metabolite,5-HT Receptor,Transferase
Solubility	10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (18.73 mM);DMSO:255 mg/mL (1447.05 mM)

Bioactivity

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Target IC50	5-HT1A:117 nM (EC50)
In Vivo	METHODS: To study the pain hypersensitivity of Serotonin, Serotonin (10 uM; 20 μl was intradermal injected into mice, and the mice were tested at 15, 30, 45, 60, 90, 120, 180 and 240 minutes. RESULTS: Compared with the control group receiving saline treatment, Serotonin produced a strong hypersensitivity reaction (p<0.001). METHODS: To study the role of IL-13-mediated 5-HT signaling in the pathogenesis of colitis, Serotonin (100 mg/kg) was subcutaneously injected into male IL-13-deficient mice 3 days before induction of DSS colitis, twice a day for 8 consecutive days. RESULTS: After inducing DSS colitis, the content of 5-HT in the colon of IL-13-/- mice that received Serotonin increased significantly.
In Vitro	METHODS: Mouse B16 melanoma cells were treated with Serotonin for 2 days to detect the anti-melanin production activity. RESULTS: Serotonin is slightly active or inactive in the inhibitory medium dimming, with IC50> 30 μM.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Inhibitor, inhibit, EndogenousMetabolite, Endogenous Metabolite, COMT, 5HTReceptor, 5-hydroxytryptamine Receptor, 5-hydroxytryptamine, 5-HT, 5-HT Receptor, 5HT Receptor, Serotonin Receptor, Serotonin

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Compound Identifiers

PubChem CID

5202 ↗

Key Properties

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No computed properties available.

Protocol Information

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Applications:	ELISA, ICC, IHC, WB
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, ICC, IHC, WB
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	IF, IHC-Fr, IHC-P, WB
Predicted Reactivity:	Bovine, Gallus, Human
Reactivity:	Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	IF, IHC-Fr, IHC-P, WB
Predicted Reactivity:	Mouse, Rat
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, ICC, WB
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Serotonin

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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