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Sinensetin

SKU: orb1302364

Description

Sinensetin, a polymethoxylated flavone found in citrus, exhibits antiangiogenic and anti-inflammatory properties. Research indicates it modulates lipid metabolism by promoting adipogenesis and lipolysis, making it a compound of interest for metabolic and inflammatory disease studies in vitro and in vivo.

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

Key Properties

CAS Number2306-27-6
MW372.37
Purity99.80% (May vary between batches)
FormulaC20H20O7
SMILESCOc1ccc(cc1OC)-c1cc(=O)c2c(OC)c(OC)c(OC)cc2o1
TargetTNF,PGE Synthase
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.69 mM);DMSO:25.79 mg/mL (69.26 mM)

Bioactivity

In Vivo
Sinensetin has the most potent antiangiogenesis activity and the lowest toxicity, inhibits angiogenesis by inducing cell cycle arrest in the G0/G1 phase in HUVEC culture and downregulating the mRNA expressions of angiogenesis genes flt1, kdrl, and hras in zebrafish.
In Vitro
Sinensetin promots adipogenesis in 3T3-L1 preadipocytes growing in incomplete differentiation medium, sinensetin enhances adipogenesis and lipolysis by increasing cAMP levels. Sinensetin shows anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α).

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, inhibit, hPGDS, Sinensetin, TNFR, TNF Receptor, PGE synthase, PGE Synthase, PGESynthase, Pedalitin permethyl ether, Prostaglandin E synthase, Tumor Necrosis Factor Receptor

Similar Products

  • Sinensetin [orb1222491]

    >98% (HPLC)

    2306-27-6

    372.37

    C20H20O7

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg, 1 g, 200 mg
Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 110.00
10 mg
$ 140.00
25 mg
$ 230.00
50 mg
$ 330.00
100 mg
$ 460.00
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