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(S,R,S)-AHPC-Me hydrochloride

SKU: orb1308828

Description

(S,R,S)-AHPC-Me hydrochloride, also known as VHL ligand 2 hydrochloride, is a key component for constructing PROTAC degraders like ARV-771. This potent VHL-recruiting ligand enables the targeted degradation of BET proteins, demonstrating high potency (DC50 <1 nM) in cellular models, including castration-resistant contexts.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1948273-03-7
MW481.051
Purity99.27% (May vary between batches)
FormulaC23H33ClN4O3S
SMILESO=C([C@H]1N(C([C@@H](N)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C2=CC=C(C3=C(C)N=CS3)C=C2)C.[H]Cl
TargetLigands for E3 Ligase
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.16 mM);DMSO:62 mg/mL (128.88 mM)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

E3 ligase-recruiting Moiety, E3 ligase Ligand 1, (S,R,S) AHPC Me hydrochloride, (S,R,S)AHPCMe hydrochloride, AHPC-Me Hydrochloride, inhibit, Ligand for E3 Ligase, Ligands for E3 Ligase, LigandforE3Ligase, Inhibitor, VHL, VHL ligand2, VHL ligand-2, VHL ligand 2, VHL ligand 2 Hydrochloride, VHL ligand 2 hydrochloride

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Key Properties

No computed properties available.

Protocol Information

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50 mg
$ 70.00
DispatchUsually dispatched within 5-10 working days
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