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Tegoprazan

SKU: orb1307685

Description

Tegoprazan is a potent and selective oral inhibitor of gastric H+/K+-ATPase, demonstrating in vitro IC50 values of 0.29-0.52 μM across species. It is utilized in research on gastric acid secretion, motility, and related gastrointestinal disorders, with applications in both in vitro enzymatic assays and in vivo pharmacological studies.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Tegoprazan

Key Properties

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CAS Number942195-55-3
MW387.38
Purity98.22% (May vary between batches)
FormulaC20H19F2N3O3
SMILESFC1=C2[C@H](CCOC2=CC(F)=C1)OC3=C4NC(C)=NC4=CC(C(N(C)C)=O)=C3
TargetProton pump,ATPase,Potassium Channel
SolubilityDMSO:22.5 mg/mL (58.08 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.16 mM)

Bioactivity

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Target IC50
H+, K+-ATPase:0.29-0.52 μM
In Vivo
METHODS: Tegoprazan (CJ-12420) (3, 10 mg/kg, oral, 5 days) was used to treat pylorus-ligated rats, and the effects of Tegoprazan and esomeprazole on gastric acid secretion in pylorus-ligated rats were observed. RESULTS The gastric fundus pH values ​​of 3 mg/kg Tegoprazan were 4.13 and 4.34, respectively, and the gastric fundus pH values ​​of 10 mg/kg Tegoprazan were 6.86 and 6.63, respectively. Tegoprazan can completely inhibit gastric acid secretion.
In Vitro
METHODS: BMM cells were cultured with Tegoprazan (CJ-12420) (0, 0.0005, 0.001, 0.005, 0.01, 0.05, 0.1, 0.5, 1, 10, 100 and 1000 μg/mL, 24 hours) to investigate its effects on BMM cytotoxicity and nitric oxide (NO) production. RESULTS When the concentration of Tegoprazan was 0.5, 1, 10 and 100 μg/mL, the cell viability exceeded 80%; when the concentration was 1000 μg/mL, the cell viability was less than 80%; 100 μg/mL of Tegoprazan could significantly inhibit NO production in BMM cells.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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acid, inhibit, Inhibitor, gastric, H+/K+-ATPase, secretion, pentagastrin, Tegoprazan, Proton Pump, Protonpump, Proton pump

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
23582846 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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1 mg
$ 90.00
5 mg
$ 170.00
1 ml x 10 mM (in DMSO)
$ 180.00
10 mg
$ 230.00
25 mg
$ 360.00
50 mg
$ 460.00
100 mg
$ 580.00
200 mg
$ 810.00
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