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Tesirine

SKU: orb2279239

Description

MP-PEG8-VA-PABC-PBD Dimer is a drug-linker conjugate designed for antibody-drug conjugates (ADCs). Its PBD dimer payload acts as a potent DNA alkylating agent, inhibiting DNA replication. This compound is used in cancer research for developing ADCs and has been evaluated in both in vitro cytotoxicity assays and in vivo xenograft models.

Research Area

Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1595275-62-9
MW1496.65
FormulaC75H101N9O23
SMILES[H][C@@]12CC(C)=CN1C(=O)c1cc(OC)c(OCCCCCOc3cc4N([C@@H](O)[C@]5([H])CC(C)=CN5C(=O)c4cc3OC)C(=O)OCc3ccc(NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN4C(=O)C=CC4=O)C(C)C)cc3)cc1N=C2
TargetPROTAC Linker,DNA Alkylator/Crosslinker,Drug-Linker Conjugates for ADC

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information