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Valsartan

SKU: orb1300528

Description

Valsartan (CGP 48933) is a tetrazole-based, selective angiotensin II type 1 (AT1) receptor antagonist used as an antihypertensive agent. It is widely employed in cardiovascular research, including in vitro receptor binding assays and in vivo models of hypertension and heart failure.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number137862-53-4
MW435.52
Purity>98%
FormulaC24H29N5O3
SMILESC(N([C@@H]([C@H](C)C)C(O)=O)C(CCCC)=O)C1=CC=C(C2=C(C=CC=C2)C=3NN=NN3)C=C1
TargetGPCR
SolubilitySoluble in DMSO (up to 40 mg/ml).

Bioactivity

In Vivo
Valsartan is a potent diuretic, ACE inhibitor, calcium antagonist, and β-blocker.Valsartan dose-dependently inhibited vasoconstriction of angiotensin II-induced vasoconstriction and lowered blood pressure in a renin-dependent model of hypertension.
In Vitro
Valsartan is a potent diuretic, ACE inhibitor, calcium antagonist, and β-blocker.Valsartan dose-dependently inhibited vasoconstriction of angiotensin II-induced vasoconstriction and lowered blood pressure in a renin-dependent model of hypertension.

Storage & Handling

StorageRT
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CGP-48933

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

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20 mg
$ 170.00
100 mg
$ 340.00
DispatchUsually dispatched within 5-10 working days
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