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Vazegepant hydrochloride

SKU: orb1298717

Description

Vazegepant hydrochloride is a novel intranasal CGRP receptor antagonist for the acute treatment of migraine, supported by positive Phase II/III clinical data. It is utilized in preclinical research to investigate CGRP-mediated pathways in both in vitro binding assays and in vivo models of migraine and pain.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1414976-20-7
MW675.3
Purity99.56% (May vary between batches)
FormulaC36H47ClN8O3
SMILESCl.CN1CCC(CC1)N1CCN(CC1)C(=O)[C@@H](Cc1cc(C)c2[nH]ncc2c1)NC(=O)N1CCC(CC1)c1cc2ccccc2[nH]c1=O
TargetCGRP Receptor
SolubilityDMSO:30 mg/mL (44.42 mM)

Bioactivity

Target IC50
CGRP (human):0.023 nM (Ki)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CGRP Receptor, CGRP, CGRPReceptor, COVID-19, BHV 3500, BHV3500, BHV-3500, Calcitonin gene-related peptide receptor, Inhibitor, gepant, inflammation, intranasal, inhibit, migraine, receptor, Zavegepant, soluble, Vazegepant, Vazegepant HCl, Vazegepant hydrochloride, Vazegepant Hydrochloride
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 110.00
5 mg
$ 210.00
10 mg
$ 280.00
1 ml x 10 mM (in DMSO)
$ 280.00
25 mg
$ 440.00
50 mg
$ 620.00
100 mg
$ 830.00
DispatchUsually dispatched within 5-10 working days
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