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Lenalidomide-OH

SKU: orb1218841

Description

Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1416990-08-3
MW260.25
Purity>98% (HPLC)
FormulaC13H12N2O4
SMILESO=C(C(N(CC1=C2C=CC(O)=C1)C2=O)CC3)NC3=O
TargetPROTAC
SolubilityDMSO : 11 mg/mL (42.27 mM; Need ultrasonic)

Bioactivity

In Vitro
Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

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