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Lenalidomide-OH

SKU: orb1307403

Description

Lenalidomide-OH is a cereblon (CRBN)-binding derivative of lenalidomide, designed for use as a key ligand component in constructing PROTAC molecules. It enables targeted protein degradation and is widely utilized in both in vitro and in vivo research to study ubiquitin-proteasome pathways and therapeutic modalities.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1416990-08-3
MW260.245
Purity99.77% (May vary between batches)
FormulaC13H12N2O4
SMILESO=C(C(N(CC1=C2C=CC(O)=C1)C2=O)CC3)NC3=O
TargetLigands for E3 Ligase,PROTAC Linker
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.68 mM);DMSO:11 mg/mL (42.27 mM)

Bioactivity

In Vitro
Lenalidomide-OH can be linked to a protein ligand via a linker to form PROTACs, which induce the ubiquitination-mediated degradation of cancer-promoting proteins .

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

E3 ligase-recruiting Moiety, Cereblon, Ligands for E3 Ligase, LigandforE3Ligase, Ligand for E3 Ligase, inhibit, Inhibitor, Lenalidomide OH, LenalidomideOH, Lenalidomide-OH

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    C13H12N2O4

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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50 mg
$ 70.00
1 ml x 10 mM (in DMSO)
$ 90.00
DispatchUsually dispatched within 5-10 working days
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